Mitochondrial dysfunction

The functionality of every organ and every cell is determined by a set of biochemical processes. And every biochemical reaction in the human body is an energy-consuming process. The more metabolically active a cell is, the greater the amount of energy it requires.

The energy supply of a cell depends on the number and performance of special organelles called mitochondria. One cell can contain from 200 to 2000 mitochondria; the largest number of mitochondria is found in skeletal and cardiac muscle cells, hepatocytes, and brain cells.

Naturally, in the absence of resources and "fuel," every cell will suffer and fail to perform its function; therefore, mitochondrial dysfunction leads to dysfunction and insufficiency of the cell and the organ as a whole.

The main task of mitochondria is the synthesis and resynthesis of macroergic compounds, i.e., molecules whose breakdown releases energy. The most important macroergic compound is the adenosine triphosphate (ATP) molecule.

The total energy supply resulting from the work of all mitochondria of all cells of the body is defined as "mitochondrial function," and the reduction of mitochondrial pool capacity, accordingly, is "mitochondrial dysfunction."

Impairment of mitochondrial function also includes primary mitochondrial pathology, a group of severe genetically mediated diseases that belong to the group of orphan diseases (link to the "Orphan Diseases" section).

Mitochondrial dysfunction is a clinical-laboratory phenomenon. The clinical picture and spectrum of complaints in mitochondrial dysfunction are extremely wide:

Mitochondrial dysfunction is not a metaphorical concept. Verification and determination of the degree of mitochondrial dysfunction development is carried out using metabolomic laboratory tests. (Link to the interpretation service).

From the perspective of biochemical processes, mitochondrial dysfunction can be:

According to the severity and duration of the process, acute compensatory mitochondrial dysfunction, subcompensated, and decompensated are distinguished.

Correction of mitochondrial dysfunction is a long and labor-intensive process of work by a team of specialists, which includes comprehensive metabolic and anti-inflammatory therapy, mandatory hormonal support, as well as specialized rehabilitation measures combined into the REMIT program, including hyperoxygenation, interval hypoxic therapy, and ozone therapy https://planetamed.ru/uslugi/remit/

More details about the significance of mitochondrial dysfunction in the development of neuroinflammation and psychoneurological disorders can be found in the lecture course on the Ketogenic Diet as the main part of metabolic and mitochondrial therapy https://planetamed.ru/category/lektoriy/ and in the lecture course on Neurobiochemistry and Immunology https://planetamed.ru/courses/neyrobiokhimiya-i-immunologiya-ras/