REMIT

REMIT Mitochondrial Rehabilitation

Mitochondrial function underlies a number of somatic and neuropsychiatric disorders. Total energy supply resulting from the operation of all mitochondria in all cells of the body is defined as "mitochondrial function," and a reduction in the capabilities of the mitochondrial pool is defined, accordingly, as "mitochondrial dysfunction." (For more details, see the section "Mitochondrial Dysfunction")

Correction of mitochondrial dysfunction is a lengthy and labor-intensive process involving a team of specialists, which includes comprehensive metabolic and anti-inflammatory therapy, mandatory hormonal support, as well as specialized rehabilitation procedures combined into the REMIT program, including interval hypoxia therapy, hyperbaric oxygenation, and ozone therapy.

Interval Hypoxia Therapy

Summative mitochondrial function is determined by the work of all mitochondria, but the aggregate of mitochondria is heterogeneous. In patients with mitochondrial dysfunction, some mitochondria are in an active functional state, while others are altered in size and shape, biologically ineffective, and inefficient. The quantitative composition of this heterogeneous group of mitochondria remains constant (i.e., while "bad" mitochondria take up space, new "good" mitochondria do not form).

Hypoxia therapy is a physiotherapeutic method of interval hypoxic training aimed at regulating the operation of the mitochondrial pool.

The mechanism of action of the method is based on the ability to activate regulatory and adaptive systems, including the pituitary-adrenal, nervous, and endocrine systems, which leads to the restoration of internal homeostasis against the backdrop of normal oxygen metabolism.

In addition to affecting the mitochondrial pool, interval hypoxia therapy changes energy metabolism as a whole by stimulating antioxidant mechanisms, increasing kidney production of erythropoietin, etc. Technically, interval hypoxia therapy is conducted as inhalations of a gas mixture with varying concentrations of oxygen (from elevated to reduced). Under the control of psychological and somatic condition, heart rate, saturation, and the ratio of saturation to oxygen concentration in the supplied mixture, interval training modes are changed. Procedures are carried out daily, with the duration of the course varying from 12 days to 40 consecutive days.

There is no special preparation for hypoxia therapy; it can be carried out in parallel with taking medications and other treatment schemes.

Interval hypoxia therapy is also used as an independent treatment method, but we achieve the maximum effect when combined with hyperbaric oxygenation and ozone therapy (REMIT program) and infusion therapy.

Hyperbaric Oxygenation

The need of organs and systems for oxygen varies. Tissues of the most metabolically and biochemically active organs are most sensitive to oxygen deficiency, especially cells of the cardiovascular system and central nervous system.

A hyperbaric chamber is a medical rehabilitation procedure designed to saturate body tissues with oxygen under elevated pressure (hyperbaric oxygenation). The increased oxygen concentration makes it possible to combat the consequences of hypoxic processes and activate mitochondrial processes. Hyperoxia is used in the complex treatment of various pathological conditions and chronic diseases.

During the procedure, the patient stays for a certain time in a special chamber with a large amount of oxygen supplied under pressure. During the procedure, the incoming oxygen binds to the blood and is carried throughout the body, compensating for its deficiency. The procedure is tolerated calmly by patients of various ages, but it is necessary to take into account contraindications and follow certain rules.

Contraindications for hyperbaric hyperoxia:

• Serious lung pathologies (air cysts, abscesses);
• Acute and chronic impaired patency of the Eustachian tubes;
• Acute respiratory diseases;
• Severe purulent infections.

Should be taken into account:

• Underwear must not contain synthetic, wool, or silk fibers (cotton clothing only). 
• It is strictly forbidden to use wraps or any ointment dressings during the procedure. 
• You should visit the hyperbaric chamber with clean hair and body, strictly without cosmetics on the skin (including creams). 
• Before the procedure, jewelry, watches, metal, and plastic items and objects should be removed.
• You should not bring foreign items into the hyperbaric chamber (phone, books, etc.).

The procedure lasts from 15 minutes to 60 minutes (depending on indications and clinical situation), with a course of 12-14 days, in parallel with interval hypoxia therapy and ozone therapy.

Ozone Therapy

The history of studying the use of ozone for medical purposes is quite long due to its pronounced and easily achievable bactericidal effect.

Main therapeutic effects achieved with ozone therapy:

• immunomodulatory action: antiviral, bactericidal, antifungal effect; regenerative effects, increased neuroplasticity;
• antise