ALS is a progressive disease of the nervous system, which damages the nerve fibers that innervate the muscles, so the clinical picture is dominated by symptoms associated with damage to motor functions - muscle twitching, weakness, muscle stiffness.

Damage to the lower motor neurons (neurons of the spinal cord) is distinguished, which disrupts walking, a person begins to stumble, walk uncertainly up and down the stairs, fine motor skills in the hands, handwriting, etc. are impaired.

When the upper motor neurons (originating from the brain) are involved, facial muscles weaken, a nasal voice appears, chewing and swallowing are impaired.

The symptoms increase very quickly, loss of muscle strength disables the patient, it becomes difficult for him to move, walk independently, and take care of himself. With progression of paresis of the diaphragm and respiratory muscles, breathing disorders develop, oxygen support is required, swallowing disorders lead to difficulties in eating, patients are given a gastrostomy.

Currently, the cause of ALS is unknown, there is no treatment for ALS, only symptomatic therapy is prescribed, life expectancy with this disease rarely exceeds 3-5 years.

Diagnostics of ALS is based on the clinical picture, results of electromyography ENMG, MRI of the brain and spinal cord, sometimes biopsy results.

Several theories of ALS development are considered.

Immunological. It is assumed that microglia (immune cells of the central nervous system, macrophages) reduces its protective activity, while pathogenic microorganisms are activated, this leads to damage to neurons. The more neurons are damaged, the faster the process of damage to healthy neurons increases. It is not possible to identify the leading pathogen.

Mitochondrial theory. A decrease in energy production in nerve cells leads to conductivity impairment, reduces the level of electrical signal production, which is necessary for muscle contraction. Therefore, drugs with a mitochondrial effect are added to the treatment.

Oxidative stress theory. An increase in the number of free radicals with mitochondrial dysfunction and impaired oxygen utilization leads to damage to the cells of the nervous system. Therefore, with ALS, it is necessary to carry out antioxidant therapy.

In general, there is currently no cure for ALS or ALS treatment in the world, existing programs only accompany the patient as he or she fades. However, this does not mean that research and attempts to find new approaches to treating this disease with an extremely unfavorable outcome have ceased.

On the websites of foreign clinics, you can find invitations to join experimental research groups that test new drugs and treatment regimens for ALS.

In our clinic, we consult patients with ALS; our approaches are based on the immuno-mitochondrial concept of the development of degenerative diseases of the nervous system. Our positive experience in treating multiple sclerosis, dementia, autism, Parkinson's disease, built on this concept, shows its validity when used in pathogenetically close, although different in external manifestations, conditions.

Therefore, in situations where there are no treatment options, the prognosis for the disease is fatal, you have the right to try all potentially promising treatment regimens.

Sign up for a consultation through the clinic administrator, the sooner you contact, the more noticeable the work will be.

When patients contact us already at terminal stage of the process, as a rule, it is already unrealistic to help them.

Specialists

Generalov Vasily Olegovich

Professor, Doctor of Medical Sciences, Head of the...

Arrange an appointment

Новое скрытое поле

Send